Assistant Professor, UCSD
Roger Tsien Chancellor’s Faculty Fellow
Departments of Pharmacology and Chemistry & Biochemistry
University of California, San Diego
Head of the
4D Computer Science, Engineering, Lattice Light-Sheet, Biology Laboratory
UC San Diego
PI of the 4D CELL Biology Lab
UC Berkeley
Postdoc in lattice light-sheet microscopy, organoids and AI-based data analysis, Betzig Lab & Drubin Lab
Postdoc in optical engineering and membrane biophysics, Hurley Lab & Bustamante Lab
Max Planck Institute for Molecular Genetics Berlin / Free University Berlin
PhD Computer Science / Biophysics
Computational Molecular Biology, Prof. Frank Noé
Thesis: 'Reaction-diffusion dynamics in biologial systems - theory, computation, modeling and simulation. Application to the visual cascade and the synaptic vesicle cycle.'
MSc Bioinformatics
Completion in one year (instead of two as listed in the curriculum).
Thesis: 'Investigation of the reaction-diffusion processes of rod cell disc membrane photoactivation with single-particle resolution'
Advisor: Frank Noé
Fast Track program for outstanding young researchers
(Skip masters degree and advance to PhD with the BSc immediately. The Fast Track program included 1 year of courses before an exam would grant immediate advance to the PhD. I chose to do the 2 year MSc curriculum in that year. I successfully passed the Fast Track and additionally got the MSc.)
Saarland University
Thesis: 'MHC:peptide structure prediction' with fast constraint based MD-Simulation substitute
Advisor: Rainer Böckmann
I combined confocal microscopy with optical trapping to measure force and fluorescence of proteins acting on small membrane nanotubes (pulled from e.g. a giant unilamellar vesicles (GUV)). These nanotubes allow studying protein-membrane biophysics in tubular, highly curved topologies. They resemble vesicle necks found e.g. in normal topology budding (e.g. Clathrin mediated endocytosis) and reverse topology budding (ESCRT system).
The Confleezers: Left:The Confleezers 1.0 that combines confocal microscopy with optical tweezing. Right: Membrane nanotubes pulled from model membranes using micromanipulators (top) and the trap of the Confleezers (bottom).
See our applications on the ESCRT system and our review:
J Schöneberg, M R Pavlin*, S Yan*, M Righini, I-H Lee, L-A Carlson, A H Bahrami, D H Goldman, X Ren, G Hummer, C Bustamante and J H Hurley (2018) ATP-dependent force generation and membrane scission by ESCRT-III and Vps4, Science, 362 (6421), 1423-1428. * equal contribution.
J Schöneberg*, Lee IH*, Iwasa JH, Hurley JH, (2016) Reverse-topology membrane scission by the ESCRT proteins. Nature Reviews Molecular Cell Biology, doi: 10.1038/nrm.2016.12. (*equal contribution).
J Schöneberg*, M Lehmann*, A Ullrich, Y Posor, W-T Lo, G Lichtner, J Schmoranzer, V Haucke, F Noé, (2017) Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission. Nature Communications 8, 15873 doi: 10.1038/ncomms15873. (*equal contribution).
See our contributions to the rod cell visual cascade: Structure 2015: Higher-order architecture of rhodopsin in intact photoreceptors and its implication for phototransduction kinetics. Biophysical Journal 2014: Explicit Spatiotemporal Simulation of Receptor-G Protein Coupling in Rod Cell Disk Membranes.
ReaDDy is a particle-based reaction-diffusion simulation software. It features
simulation in and on arbitrary geometries (i.e. 3D, 2D, spherical,...),
spatial confinement (walls, boxes, tubes, ...),
excluded volume of particles (crowding effects) and
particle-particle interaction potentials (repulsion, attraction, clustering, ...).
See more under readdy-project.org, contribute under gitHub/readdy and read the paper under Schöneberg and Noé, PLOS ONE, 2013. Also check out the newest ReaDDy developments here.
2022
2018
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2015
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2012
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2003
NIH Director's New Innovator Award 2022 (DP2)
Best Presentation, Developmental and Cell Biology Division Posters, Asilomar
Siebel Scholars Stem Cell Fellowship
Elected Chair of the 2019 GRS Gordon Research Seminar on 'Molecular Membrane Biology'
Tiburtius Annerkennungs Prize for best PhD thesis of the universities of Berlin
Marie Skłodowska-Curie postdoctoral fellowship
Poster Award, 4th International caesar Conference
Steering committee member Junges Wissenschaftsforum Dahlem, FU-Berlin
Chosen student, Excellence Initiative Proposal , FU-Berlin
Best Poster Award, IMPRS-CBSC, MPI-Molgen Berlin
IMPRS-CBSC fellowship for doctoral studies, MPI-Molgen Berlin
Fast Track fellowship, IMPRS-CBSC, MPI-Molgen Berlin
Konrad Adenauer fellowship for undergraduate studies
German Federal Cultural Foundation grant
Barmer Award for best high school diploma in biology
Scheffel Award for best high school diploma in German
Young Leaders Academy
Saarland Academy for highly gifted people
2017 - 2019
The 2019 GRS with its 53 participants and including our Keynote Speaker Randy Schekman and our Career Mentors Roberto Zoncu and Laura Lackner.
Liz and me with the freshly elected chairs of the 2021 meeting. (Left to right: Raquel Salvador Gallego, Joh Schöneberg, Liz Costa, Priya Gurumoorthy)
2017 - 2018
2015 - 2016
2011 - 2014
Co-Founder and West Coast Regional Coordinator
Marie Curie Alumni Association North America Chapter
MCAA, Washington, DC, USA
Co-Chair
Berkeley Postdoctoral Entrepreneurship Program (BPEP)
UC Berkeley, CA, USA
Co-Founder and Member
Young Science Forum Dahlem (German Research Excellence Initiative)
FU Berlin, Germany